汪寅生 出生年月：1971年1月 学历与职称：博士、长江学者讲座教授 专业方向：分析化学 Email：Yinsheng.Wang@ucr.edu
教育与研究经历 1989.9-1993.7 山东大学化学系 学士 1993.9-1996.7 中科院大连化学物理所 硕士 1996.9-2001.7 Washington University in St. Louis 博士 2001.9-2005.7 University of California, Riverside. Assistant Professor 2005.8-2008.7 University of California, Riverside. Associate Professor 2008.8- University of California, Riverside. Professor 2008.8- University of California, Riverside. Director, Environmental Toxicology Graduate Program 2016.3- 武汉大学 长江学者讲座教授 研究领域与兴趣 长期从事质谱分析在生物医学中的应用，涉及研究领域包括蛋白质组学、DNA损伤和修复、表观遗传学、环境毒理学等。建立了DNA损伤的质谱分析研究体系，阐明了一系列DNA损伤产物的形成、修复及生物效应；结合蛋白质组学和质谱分析，研究了一系列抗癌药物的药理机制，以及环境有害物质的毒理机制。从2001年至今，主持和参与了20 多项美国NIH 等资助项目，以主持人身份获得超过1600万美元的经费资助。迄今，已在Nature Chemical Biology, PNAS, Journal of the American Chemical Society, Molecular & Cellular Proteomics, Nucleic Acid Research, Analytical Chemistry, Journal of Proteome Research等学术期刊上发表原始研究和综述论文约200篇。 代表性成果 1. You, C. and Wang, Y.* Mass spectrometry-based quantitative strategies for assessing the biological consequences and repair of DNA adducts.Acc. Chem. Res., 2016, 49, 205-213. 2. Liu, S. and Wang, Y.* Mass spectrometry for the assessment of the occurrence and biological consequences of DNA adducts.Chem. Soc. Rev. 2015, 44, 7829-7854. 3. Wang, P., Amato, N.J., Zhai, Q. and Wang, Y.* Cytotoxic and mutagenic properties ofO4-alkylthymidine lesions inEscherichia colicells.Nucleic Acids Res., 2015, 43, 10795-10803. 4. You, C. and Wang, Y.* Quantitative measurement of transcriptional inhibition and mutagenesis induced by site-specifically incorporated DNA lesionsin vitroandin vivo.Nat Protoc, 2015, 10, 1389-1406. 5. Zhang, F., Paramasivam, M., Cai, Q., Dai, X., Wang, P., Lin, K., S, J., Seidman, M.M. and Wang, Y.* Arsenite binds to the RING finger domains of RNF20-RNF40 histone E3 ubiquitin ligase and inhibits DNA double-strand break repair.J. Am. Chem. Soc., 2014,136, 12884-12887. 6. Fu, L., Guerrero, C.R., Zhong, N., Amato, N.J., Liu, Y., Liu, S., Cai, Q., Ji, D., Jin, S.G., Niedernhofer, L.J., Pfeifer, G.P., Xu, G.L., Wang Y.* Tet-mediated formation of 5-hydroxymethylcytosine in RNA. J. Am. Chem. Soc., 2014,136, 11582-11585. 7. Zhai, Q., Wang, P., Cai, Q. and Wang, Y.* Syntheses and characterizations of thein-vivoreplicative bypass and mutagenic properties of the minor-grooveO2-alkylthymidine lesions.Nucleic Acids Res., 2014,42, 10529-10537. 8. Xiao, Y., Guo, L. and Wang, Y.* A targeted quantitative proteomics strategy for global kinome profiling of cancer cells and tissues.Mol. Cell. Proteomics, 2014,13, 1065-1075. 9. Liu, S., Wang, J., Su, Y., Guerrero, C., Zeng, Y., Mitra, D., Brooks, P.J., Fisher, D.E., Song, H. and Wang, Y.* Quantitative assessment of Tet-induced oxidation products of 5-methylcytosine in cellular and tissue DNA.Nucleic Acids Res., 2013,41, 6421-6429. 10. You, C., Dai, X., Yuan, B., Wang, J., Wang, J.S., Brooks, P. J., Niedernhofer, L. J., Wang, Y.* A quantitative assay for assessing the effects of DNA lesions on transcription.Nat. Chem. Biol., 2012,8, 817-822. 11. Yuan, B.F., Zhang, J., Wang, H., Xiong, L., Cai, Q., Wang, T., Jacobsen, S., Pradhane, S. and Wang, Y.* 6-Thioguanine reactivates epigenetically silenced genes in acute lymphoblastic leukemia cells by facilitating proteasome-mediated degradation of DNMT1,Cancer Res., 2011,71, 1904-1911. 12. Yuan, B.F., Cao, H., Jiang, Y., Hong, H. and Wang, Y.* Efficient and accurate bypass ofN2-(1-carboxyethyl)-2'-deoxyguanosine by DinB DNA polymerase in vitro and in vivo.Proc. Natl. Acad. Sci. U S A., 2008, 105, 8679-8684. 获奖与荣誉 2005 年获美国质谱学会研究奖（Research Award, the American Society for Mass Spectrometry）； 2012 年获得美国化学毒理研究青年科学家奖（Chemical Research in Toxicology Young Investigator Award）； 2012 年被选为 “美国科学促进会”会士（Fellow, The American Association for the Advancement of Science）； 2013 年获得美国质谱学会“The Biemann Medal”（该奖项授予那些长期在质谱基础和应用领域做出突出贡献的个人）。 |
